Ultrasound Neuromodulation and Theranostics

We study the biological mechanisms and possible translational strategies of using ultrasound to modulate cellular activities (i.e., neuromodulation or immunotherapy), investigate the potential of ultrasonic bioeffects for cancer therapy and diabetes, and develop multimodality molecular imaging and theranostics. Specifically, we develop (1) “sonogenetics,” a cell-type-specific and spatiotemporally accurate ultrasound modulation method; and (2) nanoparticle-mediated ultrasound modulation for cell-type-specific and accurate neural circuit activation of targeted neurons for distinct behaviors. Our studies are based on the understanding and identification of responsible molecular mechanisms of ultrasound modulation, especially the role of mechanosensitive ion channels. We also include other ultrasound-responsive cells in our studies, such as immune and beta cells.