• 2026

    Wu, Y., Zhao, X., Jiang, Y., Chen, C., Liu, L., Hou, X., Xian, Q., Guo, J., & Sun, L. (2026). Microbubble-enhanced ultrasound stimulation of β-cells improves insulin release and glycemic control in mice. Journal of Nanobiotechnology, 24(1), 77. https://doi.org/10.1186/s12951-025-03926-6

    He, J., Zhu, J., Wang, X., Chen, Z., Yang, J., Yuan, Z., Xu, H., Sun, L., & Qiu, Z. (2026). Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound. Advanced Science, e15991.

    https://doi.org/10.1002/advs.202515991

    Lei, T., Xian, Q., Li, D., Su, M., Wu, Y., Hou, X., Jing, J., Jiang, Y., Huang, X, Wong, K. F., Zhu, J.,Guo, J., Qiu, Z., & Sun, L. (2026). Rapid rescue of despair behaviors by sonogenetic neuromodulation of the mPFC-DRN pathway. Molecular Psychiatry, 1-14. https://doi.org/10.1038/s41380-026-03616-1

    Hou, X., Jing, J., Shi, Z., Jiang, Y., & Sun, L. (2026). Sono-mechanical nanostructures-enabled sustained precise ultrasound brain stimulation. Nature Communications. https://doi.org/10.1038/s41467-026-69710-8

    2025

    Xian, Q., Li, D., Zhao, X., Zhao, D., Jiang, Y., Jing, J., ... & Sun, L. (2025). Impact of endogenous sonosensation on in vivo sonogenetics. iScience, 28(12). https://doi.org/10.1016/j.isci.2025.114030

    Ren, X., Zhang, Y., Zhai, P., Sun, L., Li, Z., Chen, X., & Lu, M. (2025). Quantitation of acute extremity compartment syndrome in rabbits using shear-wave elastography to assess viscoelasticity. Academic Radiology. https://doi.org/10.1016/j.acra.2025.08.055

    Chen, Z., Li, N., Xi, C., He, J., Zhu, J., Wu, G., Xia, J., Fei, C., Sun, L., Xu, H., & Qiu, Z. (2025). Functional ultrasound imaging of auditory responses in comatose patients. Research, 8, 0709. https://doi.org/10.1002/advs.202515991

    Yang, J., Zhou, E., Zhu, J., Zhu, T., Zhao, J., Lin, X., Cao, Z., Chen, Z., An, Z., Sun, L., Wu,W., & Qiu, Z. (2025). Miniaturized and accessible functional ultrasound imaging system for freely moving mice. bioRxiv, 2025-04. https://doi.org/10.1101/2025.04.24.650351

    Li, Z., Qiang, Y., Chen, D., Hu, D., Gao, D., Xu, X., Sun, L., Li, Y., Qiu, W., & Sheng, Z. (2025). Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres. Materials Today Bio, 31, 101513. https://doi.org/10.1016/j.mtbio.2025.101513

    Hou, X., Liu, L., & Sun, L. (2025). Precise modulation of cell activity using sono-responsive nano-transducers. Biomaterials, 314, 122857. https://doi.org/10.1016/j.biomaterials.2024.122857

    2024

    Qiu, C., Su, M., Yang, S., Liu, B., Jia, N., Xu, Z., Zheng, H., Sun,L., Qiu, W., & Li, F. (2024). Textured-piezoelectric-ceramic-based focused intravascular ultrasonic transducer with improved image quality and uniformity. Applied Physics Letters, 125(23). https://doi.org/10.1063/5.0237897

    Qiang, Y., Huang, W., Liang, W., Liu, R., Han, X., Pan, Y., Wang, N., Yu, Y., Zhang, Z., Sun, L., & Qiu, W. (2024). An adaptive spatiotemporal filter for ultrasound localization microscopy based on density canopy clustering. Ultrasonics, 144, 107446. https://doi.org/10.1016/j.ultras.2024.107446

    Liu, B., Su, M., Zhang, Z., Sun, L., Yu, Y., & Qiu, W. (2024). A novel coded excitation imaging platform for ultra-high frequency (> 100 mhz) ultrasound applications. IEEE Transactions on Biomedical Engineering, 72(4), 1298-1305. https://doi.org/10.1109/TBME.2024.3496843

    Li, N., Chen, Z., Zhu, J., Zheng, H., Xia, J., Yuan, Z., Fei, C., Sun, L., & Qiu, Z. (2024). Simultaneous Focused Ultrasound Neuromodulation and Fiber Photometry Recording in Free-moving Mouse. JoVE (Journal of Visualized Experiments), (211), e67090. https://dx.doi.org/10.3791/67090 https://dx.doi.org/10.3791/67090

    Zhu, J., He, D., Sun, M., Zheng, H., Chen, Z., Yang, J., Lin, C., Yuan, Q., Shi, YS., Sun, L., & Qiu, Z. (2024). Functional Imaging of Developing Brain in Mice and Non-Human Primates. bioRxiv, 2024-06. https://doi.org/10.1101/2024.06.07.596778

    Cheung, T., Yee, B. K., Chau, B., Lam, J. Y. T., Fong, K. H., Lo, H., Li, T. M. H., Li, A. M., Sun, L., Beisteiner, R., & Cheng, C. P. W. (2024). Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial. Frontiers in neurology, 15, 1364270. https://doi.org/10.3389/fneur.2024.1364270

    Hou, X., Jing, J., Jiang, Y., Huang, X., Xian, Q., Lei, T., Zhu, J., Wong, K. F., Zhao, X., Su, M., Li, D., Liu, L., Qiu, Z., & Sun, L. (2024). Nanobubble-actuated ultrasound neuromodulation for selectively shaping behavior in mice. Nature communications, 15(1), 2253. https://doi.org/10.1038/s41467-024-46461-y

    2023

    Yong, W., He, D., Chen, T., Rui, Z., Wen, Y., Wong, K. F., Sun, L., Qi, X. & Guo, J. (2023). Activation of N-Methyl-D-aspartate receptor contributed to the ultrasonic modulation of neurons in vitro. Biochemical and Biophysical Research Communications, 676, 42-47. https://doi.org/10.1016/j.bbrc.2023.07.034

    Jiang, Y., Hou, X., Zhao, X., Jing, J., & Sun, L. (2023). Tracking adoptive natural killer cells via ultrasound imaging assisted with nanobubbles. Acta biomaterialia, 169, 542–555. https://doi.org/10.1016/j.actbio.2023.07.058

    Wu, Y., Que, Y., Chen, J., Sun, L., Guo, J., & Ruan, Y. C. (2023). CFTR modulates hypothalamic neuron excitability to maintain female cycle. International journal of molecular sciences, 24(16), 12572. https://doi.org/10.3390/ijms241612572

    Xian, Q., Qiu, Z., Murugappan, S., Kala, S., Wong, K. F., Li, D., Li, G., Jiang, Y., Wu, Y., Su, M., Hou, X., Zhu, J., Guo, J., Qiu, W., & Sun, L. (2023). Modulation of deep neural circuits with sonogenetics. Proceedings of the National Academy of Sciences of the United States of America, 120(22), e2220575120. https://doi.org/10.1073/pnas.2220575120

    Zhu, J., Xian, Q., Hou, X., Wong, K. F., Zhu, T., Chen, Z., He, D., Kala, S., Murugappan, S., Jing, J., Wu, Y., Zhao, X., Li, D., Guo, J., Qiu, Z., & Sun, L. (2023). The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation. Proceedings of the National Academy of Sciences of the United States of America, 120(18), e2300291120. https://doi.org/10.1073/pnas.2300291120

    Li, N., Chen, Z., Zhu, J., Choi, M. H., Yang, J., Yuan, Z., Sun, L., Fei, C., & Qiu, Z. (2023). Measuring sound velocity based on acoustic resonance using multiple narrow band transducers. Heliyon, 9(3). https://doi.org/10.1016/j.heliyon.2023.e14227

    Zhu, T., Guo, J., Wu, Y., Lei, T., Zhu, J., Chen, H., Kala, S., Wong, K. F., Cheung, C. P., Huang, X., Zhao, X., Yang, M., & Sun, L. (2023). The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia. iScience, 26(2), 105993. https://doi.org/10.1016/j.isci.2023.105993

    2022

    Liu, B., Su, M., Zhang, Z., Liu, R., Sun, L., Zheng, H., & Qiu, W. (2022). A novel dual-element catheter for improving non-uniform rotational distortion in intravascular ultrasound. IEEE Transactions on Biomedical Engineering, 70(6), 1768-1774. https://doi.org/10.1109/TBME.2022.3226955

    Zhou, Y., Huang, X., Li, J., Zhu, T., Pang, W., Chow, L., Nie, L., Sun, L., & Lai, P. (2022). Small animal in situ drug delivery effects via transdermal microneedles array versus intravenous injection: a pilot observation based on photoacoustic tomography. Pharmaceutics, 14(12), 2689. https://doi.org/10.3390/pharmaceutics14122689

    Liu, T., Choi, M. H., Zhu, J., Zhu, T., Yang, J., Li, N., Chen, Z., Xian, Q., Hou, X., He, D., Guo, J., Fei, C., Sun, L., & Qiu, Z. (2022). Sonogenetics: Recent advances and future directions. Brain stimulation, 15(5), 1308–1317. https://doi.org/10.1016/j.brs.2022.09.002

    Tang, L., Si, J., Sun, L., Mao, G., & Yu, S. (2022). Assessment of the mental workload of trainee pilots of remotely operated aircraft using functional near-infrared spectroscopy. BMC neurology, 22(1), 160. https://doi.org/10.1186/s12883-022-02683-5

    Guo, J., Wu, Y., Gong, Z., Chen, X., Cao, F., Kala, S., Qiu, Z., Zhao, X., Chen, J. J., He, D., Chen, T., Zeng, R., Zhu, J., Wong, K. F., Murugappan, S., Zhu, T., Xian, Q., Hou, X., Ruan, Y. C., Li, B., … Sun, L. (2022). Photonic Nanojet-Mediated Optogenetics. Advanced science, 9(12), e2104140. https://doi.org/10.1002/advs.202104140

    Zhong, T., Qiu, Z., Wu, Y., Guo, J., Li, H., Yu, Z., ... & Lai, P. (2022). Optically selective neuron stimulation with a wavefront shaping‐empowered multimode fiber. Advanced Photonics Research, 3(3), 2100231. https://doi.org/10.1002/adpr.202100231

    2021

    Wang, B., Zhou, Y., Wang, Y., Li, X., He, L., Wen, Z., Cao, T., Sun, L., & Wu, D. (2021). Three-dimensional intravascular ultrasound imaging using a miniature helical ultrasonic motor. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 69(2), 681-690. https://doi.org/10.1109/TUFFC.2021.3132607

    Song, L., Hou, X., Wong, K. F., Yang, Y., Qiu, Z., Wu, Y., Hou, S., Fei, C., Guo, J., & Sun, L. (2021). Gas-filled protein nanostructures as cavitation nuclei for molecule-specific sonodynamic therapy. Acta biomaterialia, 136, 533–545. https://doi.org/10.1016/j.actbio.2021.09.010

    Xian, Q., Qiu, Z., Kala, S., Wong, K. F., Murugappan, S., Wu, Y., Hou, X., Zhu, J., Guo, J., & Sun, L. (2021). Circuit-specific sonogenetic stimulation of the deep brain elicits distinct signaling and behaviors in freely moving mice. bioRxiv, 2021-11. https://doi.org/10.1101/2021.11.06.467579

    Hou, X., Qiu, Z., Xian, Q., Kala, S., Jing, J., Wong, K. F., Zhu, J., Guo, J., Zhu, T., Yang, M., & Sun, L. (2021). Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators. Advanced science, 8(21), e2101934. https://doi.org/10.1002/advs.202101934

    Wang, D., Lin, P., Chen, Z., Fei, C., Qiu, Z., Chen, Q., Sun, X., Wu, Y., & Sun, L. (2021). Evolvable acoustic field generated by a transducer with 3D-Printed Fresnel lens. Micromachines, 12(11), 1315. https://doi.org/10.3390/mi12111315

    Xie, F., Xu, S., Lu, Y., Wong, K. F., Sun, L., Hasan, K. M. M., ... & Cheng, S. H. (2021). Metformin accelerates zebrafish heart regeneration by inducing autophagy. NPJ Regenerative medicine, 6(1), 62. https://doi.org/10.1038/s41536-021-00172-w

    Su, M., Xia, X., Liu, B., Zhang, Z., Liu, R., Cai, F., Qiu, W., & Sun, L. (2021). High frequency focal transducer with a Fresnel zone plate for intravascular ultrasound. Applied Physics Letters, 119(14). https://doi.org/10.1063/5.0070313

    Xian, Q., Qiu, Z., Kala, S., Guo, J., Zhu, J., Wong, K. F., Guo, S. S. Y., Zhu, T., Hou, X., & Sun, L. (2021). Protocol for the sonogenetic stimulation of mouse brain by non-invasive ultrasound. STAR protocols, 2(2), 100393. https://doi.org/10.1016/j.xpro.2021.100393

    Xian, Q., Qiu, Z., Kala, S., Wong, K. F., Guo, J., & Sun, L. (2021). Behavioral and Functional Assessment of Ultrasound Neuromodulation on Caenorhabditis Elegans. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 68(6), 2150–2154. https://doi.org/10.1109/TUFFC.2021.3057873

    Liu, C., Yang, Y., Qiu, W., Chen, Y., Dai, J., & Sun, L. (2021). Quantitative characterization of the colorectal cancer in a rabbit model using high-frequency endoscopic ultrasound. Ultrasonics, 110, 106289. https://doi.org/10.1016/j.ultras.2020.106289

    2020

    Wang, H., Yang, X., Hou, J., Li, X., Sun, L., Jiang, J., & Zhou, Q. (2020). Application of transcutaneous laryngeal ultrasonography in the diagnosis of vocal fold polyps. Ultrasound in Medicine & Biology, 46(9), 2293-2302. https://doi.org/10.1016/j.ultrasmedbio.2020.05.014

    Qiu, Z., Kala, S., Guo, J., Xian, Q., Zhu, J., Zhu, T., Hou, X., Wong, K. F., Yang, M., Wang, H., & Sun, L. (2020). Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound. Cell reports, 32(7), 108033. https://doi.org/10.1016/j.celrep.2020.108033

    Song, L., Wang, G., Hou, X., Kala, S., Qiu, Z., Wong, K. F., Cao, F., & Sun, L. (2020). Biogenic nanobubbles for effective oxygen delivery and enhanced photodynamic therapy of cancer. Acta biomaterialia, 108, 313–325. https://doi.org/10.1016/j.actbio.2020.03.034

    Xu, S., Xie, F., Tian, L., Fallah, S., Babaei, F., Manno, S. H., Manno III, F. A. M., Zhu, L., Wong, K. F., Liang, Y., Ramalingam, R., Sun, L., Wang, X., Plumb, R., Gethings, L., Lam, Y. W., & Cheng, S. H. (2020). Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish. Journal of Endocrinology, 245(1), 39-51. https://doi.org/10.1530/JOE-19-0413

    Wang, G., Song, L., Hou, X., Kala, S., Wong, K. F., Tang, L., Dai, Y., & Sun, L. (2020). Surface-modified GVs as nanosized contrast agents for molecular ultrasound imaging of tumor. Biomaterials, 236, 119803. https://doi.org/10.1016/j.biomaterials.2020.119803

    2019

    Song, L., Wang, G., Hou, X., Kala, S., Qiu, Z., Wong, K., Cao,F., & Sun, L. (2019). Development of Nano Oxygen Carrier for Enhanced Cancer Therapy. Available at SSRN 3493850. https://dx.doi.org/10.2139/ssrn.3493850

    Qiu, Z., Guo, J., Kala, S., Zhu, J., Xian, Q., Qiu, W., Li, G., Zhu, T., Meng, L., Zhang, R., Chan, H. C., Zheng, H., & Sun, L. (2019). The Mechanosensitive Ion Channel Piezo1 Significantly Mediates In Vitro Ultrasonic Stimulation of Neurons. iScience, 21, 448–457. https://doi.org/10.1016/j.isci.2019.10.037

    Liu, Z., Au, M., Wang, X., Chan, P. M. B., Lai, P., Sun, L., Zheng, Y., Rong, L., & Wen, C. (2019). Photoacoustic imaging of synovial tissue hypoxia in experimental post-traumatic osteoarthritis. Progress in biophysics and molecular biology, 148, 12-20. https://doi.org/10.1016/j.pbiomolbio.2018.03.009

    2018

    Liu, C., Li, S., Gu, Y., Xiong, H., Wong, W. T., & Sun, L. (2018). Multispectral photoacoustic imaging of tumor protease activity with a gold nanocage-based activatable probe. Molecular imaging and biology, 20(6), 919-929. https://

    doi.org/10.1007/s11307-018-1203-1

    Song, L., Huang, Y., Hou, X., Yang, Y., Kala, S., Qiu, Z., Zhang, R., & Sun, L. (2018). PINK1/Parkin-mediated mitophagy promotes resistance to sonodynamic therapy. Cellular Physiology and Biochemistry, 49(5), 1825-1839. https://doi.org/10.1159/000493629

    Liu, C., Yan, F., Xu, Y., Zheng, H., & Sun, L. (2018). Invivo molecular ultrasound assessment of glioblastoma neovasculature with endoglin‐targeted microbubbles. Contrast media & molecular imaging, 2018(1), 8425495. https://doi.org/10.1155/2018/8425495

    2017

    Fei, C., Yang, Y., Guo, F., Lin, P., Chen, Q., Zhou, Q., & Sun, L. (2017). PMN-PT single crystal ultrasonic transducer with half-concave geometric design for IVUS imaging. IEEE Transactions on Biomedical Engineering, 65(9), 2087-2092. https://doi.org/10.1109/TBME.2017.2784437

    Yang, Y., Qiu, Z., Hou, X., & Sun, L. (2017). Ultrasonic characteristics and cellular properties of Anabaena gas vesicles. Ultrasound in medicine & biology, 43(12), 2862-2870. https://doi.org/10.1016/j.ultrasmedbio.2017.08.004

    Qiu, W., Xia, J., Shi, Y., Mu, P., Wang, X., Gao, M., Wang, C., Xiao, Y., Yang, G., Liu, J., Sun, L., & Zheng, H. (2017). A delayed-excitation data acquisition method for high-frequency ultrasound imaging. IEEE Transactions on Biomedical Engineering, 65(1), 15-20. https://doi.org/10.1109/TBME.2017.2687948

    Zhou, B., Leung, B. Y. K., & Sun, L. (2017). The effects of low‐intensity ultrasound on fat reduction of rat model. BioMed research international, 2017(1), 4701481. https://doi.org/10.1155/2017/4701481